| ORIGINAL ARTICLE |
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| Year : 2010 | Volume
: 17
| Issue : 2 | Page : 86-89 |
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Study of nephrotoxic potential of acetaminophen in birds
K Jayakumar1, K Mohan1, H.D. Narayana Swamy2, NB Shridhar1, MD Bayer3
1 Department of Veterinary Pharmacology and Toxicology, Veterinary College, KVAFSU, Hebbal, Bangalore, India
2 Department of Veterinary Pathology, Veterinary College, KVAFSU, Hebbal, Bangalore, India
3 Veterinary Faculty Clinics, Ningarhar University, Daronta Jalalabad, Ningarhar, Afghanistan
Correspondence Address:
K Jayakumar
Department of Veterinary Pharmacology and Toxicology, Veterinary College, KVAFSU, Hebbal, Bangalore - 560 024
India
DOI: 10.4103/0971-6580.72677 PMID: 21170252
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The present study was designed to evaluate the effect of acetaminophen on kidneys of birds by comparison with diclofenac that is used as positive control. The birds of Group I served as negative control and received normal saline, whereas Group II birds received diclofenac injection (2.5 mg/kg IM) and Group III birds received acetaminophen injection (10 mg/kg IM) for a period of seven days daily. The birds treated with diclofenac showed severe clinical signs of toxicity accompanied with high mortality and significant increase (P<0.001) in serum creatinine and uric acid concentration. The creatinine and uric acid concentrations were consistent with gross and histopathological findings. The negative control and acetaminophen-treated groups showed no adverse clinical signs, serum creatinine and uric acid concentrations were normal, and no gross or histopathological changes in kidneys were observed. Thus, it was concluded that acetaminophen can be used for treatment in birds without any adverse effect on kidneys. |
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