| ARTICLE |
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| Year : 2008 | Volume
: 15
| Issue : 2 | Page : 79-84 |
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Alterations in membrane bound alkaline phosphatase and ATPase activities in selected tissues of wistar rats during phosphamidon toxicity
K Srikanth1, Chetan P Sahitya1, V Lokanatha2, G Visweswari1, W Rajendra1
1 Department of Zoology, Division of Molecular Biology, Sri. Venkateswara University, Tirupati-517 502, India
2 Department of Biotechnology, Dravidian University, Kuppam-517425, India
Correspondence Address:
W Rajendra
Department of Zoology, Division of Molecular Biology, Sri. Venkateswara University, Tirupati-517 502
India
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The effect of phosphamidon was studied on membrane ATPases, alkaline phosphatase activity levels and lipid peroxidation in the brain and liver tissues of wistar rats during acute (6.63 mg kg-1body weight day-1), sub-acute (4.43 mg kg-1body weight day-1) and no-effect level (0.1 mg kg-1body weight day-1) doses. Significant increase in alkaline phosphatase activity and reduction in ATPase system suggest possible involvement of phosphatase as an alternative energy source during energy crisis so as to maintain normal physiological activities. In addition, alterations in the above enzyme systems coupled with hypoxic injury may also significantly alter and /or disrupt a variety of transport or permeability mediated physiological and biochemical phenomena across the membrane system and within the cell itself. Further, the ability of the animal to resist the stress from oxidative agents, induced during phosphamidon toxicity, was reflected by the increased glutathione peroxidase activity. |
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