| ARTICLE |
|
| Year : 2008 | Volume
: 15
| Issue : 2 | Page : 121-125 |
|
|
Protective effect of Ocimum sanctum on ethanol-induced oxidative stress in swiss albino mice brain
Dnyaneshwar Umrao Bawankule, Anirban Pal, Satyaprakash Gupta, Sachidanand Yadav, Amita Misra, Shubhra Rastogi, Ajit Kumar Shasany, Suman PS Khanuja, Mahendra P Darokar
Division of Genetic Resources and Biotechnology, Central Institute of Medicinal and Aromatic Plants, Kukrail Picnic Spot Road, P.O.CIMAP, Lucknow-15, India
Correspondence Address:
Anirban Pal
Division of Genetic Resources and Biotechnology, Central Institute of Medicinal and Aromatic Plants, Kukrail Picnic Spot Road, P.O.CIMAP, Lucknow-15
India
|
|
|
Chronic ethanol consumption is a medical problem with important socio-economic repercussions worldwide. Its chronic consumption enhances the oxidative damage to neurons and resulting in cell death. In this study we evaluated the protective effect of Ocimum sanctum on ethanol-induced oxidative stress in Swiss albino mice brain. Mice were divided into groups comprising of vehicle control, ethanol control, Ocimum sanctum water extract (OSWE) treatment at three doses, quercetin as a reference drug control and the treatment was given orally for 30 days. Oxidative stress and anti-oxidant related enzymes were estimated from brain homogenate. OSWE was found to inhibit the lipid peroxidation and nitric oxide and enhance the superoxide dismutase in dose dependent manner. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
