| ARTICLE |
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| Year : 2008 | Volume
: 15
| Issue : 2 | Page : 117-120 |
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Patho-biochemical studies on experimentally induced gout by administration of sodium bicarbonate in broilers
Sandeep Sodhi1, RS Brar1, HS Banga1, SS Nagra2
1 Department of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141 004, India
2 Department of Livestock Production & Management, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141 004, India
Correspondence Address:
Sandeep Sodhi
Department of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141 004
India
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Gout is a metabolic disorder that results in hyperuricemia and deposition of monosodium urate crystals in various parts of the body. The possibility of inducing gout in broiler chicks via the administration of sodium bicarbonate was investigated with the objective of developing an experimental model for gout induction, which may help in evaluating therapeutic compounds for preventing gout in chicks and would rather provide an insight into the patho-biochemical changes associated with gout. Broiler chicks given sodium bicarbonate at 5% in drinking water (Group 2) showed mortality within 5-7 days. The visceral gout was evident on necropsy. However, the gout did not develop in chicks given 1% sodium bicarbonate (Group 1). Microscopic examination revealed significant urate deposits, tubular necrosis, glomerulo-nephritis and foreign body granulomas in the renal interstitium in chicks of Group 2. These urate deposits were demonstrated by Deglantha stain and were found to be a salt of calcium (Von Kossa stain). Consistent with these findings were higher concentration of uric acid in plasma of chicks of Group 2. The study revealed that administration of 5% sodium bicarbonate in drinking water for one week is a simple method of inducing gout in 2-week-old broiler chicks. |
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