| ARTICLE |
|
| Year : 2006 | Volume
: 13
| Issue : 2 | Page : 83-87 |
|
|
Alterations in lipid peroxidation, glutathione and related enzymes in experimentally induced subacute toxicity of selenium in cow calves
Rajdeep Kaur1, Satyavan Rampal1, Sucheta Sharma2
1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences, Ludhiana-141001, India
2 Department of Biochemistry, College of Basic Sciences & Humanities, P.A.U, Ludhiana, India
Correspondence Address:
Rajdeep Kaur
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences, Ludhiana-141001
India
|
|
|
In the present study, the effect of subacute oral selenium toxicosis on the rate of lipid peroxidation, antioxidant enzymes (catalase and superoxide dismutase) and on the amount of glutathione and the enzymes related to its metabolism (glutathione-S-transferase, glutathione reductase and glutathione peroxidase) was studied in crossbred cow calves. Sodium selenite (@ 2.5 mg/kg) was administered orally to cow calves daily for 21 days and blood samples collected at different time intervals were analyzed for various biochemical parameters. The lipid peroxidation of erythrocytes increased significantly whereas reduced glutathione content decreased. The blood selenium levels showed a high positive correlation with glutathione peroxidase activity, which was significantly elevated throughout the treatment period. The activities of glutathione-S-transferase, glutathione reductase, superoxide dismutase and catalase were significantly increased. The 2.5 fold increase in lipid peroxidation and decreased glutathione levels suggested oxidative damage to erythrocytes during subacute selenium toxicosis. |
|
|
|
| [PDF Not available]* |
|
 |
|
