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| Year : 2006 | Volume
: 13
| Issue : 1 | Page : 61-64 |
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Cadmium chloride induced histopathological and biochemical changes in the testes of adult albino rats
R Aruna Devy1, B Anisa Khan2, Kumar3
1 Department of Zoology, St. Thomas College, Ranni, Kerala -689 673, India
2 Salim Ali School of Ecology and Environmental Sciences, Pondicherry University, Pondicherry - 605 014, India
3 Department of Pathology, Rajiv Gandhi College of Veterinary and Animal Sciences, Kurumbampet, Pondicherry, India
Correspondence Address:
R Aruna Devy
Department of Zoology, St. Thomas College, Ranni, Kerala -689 673
India
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Effect of Cadmium chloride administered intraperitoneally at 0.5(low-dose), 1.0 (medium-dose) and 2 (high-dose) mg/kg, body weight dose levels for 15 days was observed on the testes of adult albino rats. Cadmium chloride increased the activity of total protein by 6.5 fold; 3 and 4 fold increase occurs in the TC and TG levels. There is a significant increase occurs in the Ca++ATP-ases and 59% and 32% reduction occurs in the Mg++ATPase and Inorganic phosphatases. Histologically testes showed dose dependent seminiferous epithelial necrosis, degeneration and loss of spermatozoa. The changes were dose-dependent. These altered structural and biochemical changes associated with cadmium chloride intoxication along with altered membrane permeability may be responsible for the observed metabolic changes. |
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