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| Year : 2006 | Volume
: 13
| Issue : 1 | Page : 39-42 |
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Experimental study on acute toxic effects of N-nitrosodiethylamine in rats
Vanita Kaushal1, APS Brar2, Giridhar Soni1
1 Department of Biochemistry and Chemistry, Punjab Agricultural University, Ludhiana-141004, India
2 Department of Veterinary Pathology, Punjab Agricultural University, Ludhiana-141004, India
Correspondence Address:
APS Brar
Department of Veterinary Pathology, Punjab Agricultural University, Ludhiana-141004
India
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N-Nitrosodiethylamine is amongst the important group of carcinogens frequently present in human environment. The mechanism of toxicity of nitroso-compounds at cellular level is not clear, at least when the exposure is for short period. Therefore, the effect of varying doses of NDEA (50,100 and 200 mg/kg body weight) was studied in albino rats. Intraperitoneal administration of NDEA resulted in heart and spleen enlargement and decrease in liver weight. Hepatotoxicity was evident by a steady increase in enzyme levels of liver function test in a dose dependent manner. A significant increase in creatinine level at higher doses indicated it to be nephrotoxic as well. NDEA increased lipid peroxidation of blood and tissues in a dose dependent manner. These results were further supported by histopathological changes seen at higher doses. |
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