| ARTICLE |
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| Year : 2005 | Volume
: 12
| Issue : 1 | Page : 13-16 |
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In vivo antimutagenic effect of Semecarpus anacardium against mitomycin-C induced chromosome aberrations in mouse bone marrow cells
D Prabhu, Laila S Rajwani, PV Desai
South Gujarat University, Surat, Gujarat, India
Correspondence Address:
D Prabhu
South Gujarat University, Surat, Gujarat
India
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The antimutagenic effect of Semecarpus anacardium under in vivo conditon is studied. Mice were intraperitoneally treated with 500 mg/kg and 250 mg/kg of Semecarpus anacardium. Both 500 and 250 mg/kg b.wt. of Semecarpus anacardium were pretreated at 3h, 6h, 12h and 24h before the treatment of mitomycin-C. The dose levels 500 and 250 mg/kg both showed a significant inhibition of induced aberrations at the 12h pretreatment period. The simultaneous treatment with mitomycin-C did not show a marked decrease in the number of aberrations, similarly, Semecarpus anacardium treated after 3h and 6h of mitomycin-C treatment also did not show a significant reduction. The results on the reduction of induced chromosome aberrations clearly show that Semecarpus anacardium serves as an antioxidant because of the presence of flavanoids which scavenge free radicals. The action of Semecarpus anacardium oil extract has definite beneficial role against mitomycin-C induced mutagenicity and its administration may be protective and therapeutic. |
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