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| Year : 2004 | Volume
: 11
| Issue : 2 | Page : 75-80 |
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Efficacy and toxicity of vanadium nicotinate in diabetic rats
K Rameshkumar, SN Shah, DB Goswami, V Mohan, SL Bodhankar
Department of Pharmacology, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune - 411038, India
Correspondence Address:
S L Bodhankar
Department of Pharmacology, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune - 411038
India
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Vanadium compounds regulate blood glucose in Type I and II diabetes mellitus. The objective of the study was to evaluate the efficacy and toxicity of vanadium nicotinate on blood glucose in diabetic rats. Diabetic rats received either vanadium nicotinate (100 mg/kg/day, p.o. as a suspension in 7% Gum acacia solution, n=6) or only Gum acacia 7% (vehicle, n=6) for 21 days. Rats were maintained for additional 7 days without administration of vanadium nicotinate. On day 28 rats were sacrificed and hepatic as well as renal injury was examined in Haemotoxylin & Eosin stained sections under a light microscope. Blood samples were withdrawn by retro-orbital puncture method and were analyzed for glucose on 0, 7th, 14th, 21st and 28th day. Maximum reduction in blood glucose was observed on 21st day. The drug showed late onset and prolonged duration of hypoglycemic effect. No abnormality was detected in liver while focal tubular necrosis with severe cloudy changes was seen in kidney in vanadium nicotinate treated group after three week of administration of vanadium nicotinate. It is concluded that vanadium nicotinate (100 mg/kg) has significant hypoglycemic activity and long term administration resulted in nephrotoxicity. |
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