| ARTICLE |
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| Year : 2004 | Volume
: 11
| Issue : 2 | Page : 69-74 |
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Hepatoprotective activity of aqueous extract of leaves of Feronia elephantum correa. against thioacetamide and allyl alcohol intoxication in rats
Manjusha, KM Patil, GN Zambare, KR Khandelwal, SL Bodhankar
Department of Pharmacology, Bharati Vidyapeeth Deemed University,Poona College of Pharmacy, Pune 411038, India
Correspondence Address:
S L Bodhankar
Department of Pharmacology, Bharati Vidyapeeth Deemed University,Poona College of Pharmacy, Pune 411038
India
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The objective of the present investigation was to study hepatoprotective activity of aqueous extract of leaves of Feronia elephantum Correa to reverse the alterations caused by thioacetamide and allyl alcohol hepatotoxin. Albino rats (Wistar strain) were prophylactically treated with aqueous extract at two dose levels (400mg/kg and 800mg/kg, p.o) for seven days. On day six, rats were also given a single dose of thioacetamide (100mg/kg s.c.). Biochemical estimation viz. AST and ALT, physical examination viz., liver weight and liver volume and histopathological studies of liver sections were done on 8th day. In other experiment, after seven hours of fasting, aqueous extract was administered to rats at two dose levels (400mg/kg and 800mg/kg, p.o) and one hour later they were given a single dose of allyl alcohol (1.25%, 0.4ml/kg p.o.). On 2nd day, treatment with aqueous extract was repeated. On 3rd day, changes in body weight and necrosis index of liver were recorded followed by histopathological examination. The result, indicated that physical, biochemical and histopathological changes alongwith changes in necrosis index were restored to normal by treatment with aqueous extract. Thus hepatoprotective activity of aqueous extract of leaves of F. elephantum (400mg/kg and 800mg/kg, p.o) was confirmed and was found to be dose-dependent with multiple mechanisms. |
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