ARTICLE
Year : 2004  |  Volume : 11  |  Issue : 2  |  Page : 63-67

In vivo effects of erythrosine on mouse chromosomes


Post Graduate & Research Department of Zoology, Ethiraj College for Women, Chennai-600008 (Tamil Nadu), India

Correspondence Address:
Anitha C.P. Devi
Post Graduate & Research Department of Zoology, Ethiraj College for Women, Chennai-600008 (Tamil Nadu)
India
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The present study is an attempt to evaluate the genotoxic effect of erythrosine, a commonly used food colouring agent, on swiss albino mice. It is one of the eight permitted food colours in India. Fifty male target mice were assigned to five experimental groups viz., control, low dose, intermediate dose, high dose, intermediate reversal and control reversal. After a period of 30 days of oral administration of erythrosine the animals were sacrificed and metaphase plates were prepared. Calculation of mitotic index and scoring of chromosomal aberrations were carried out. A dose-dependent decrease in cell proliferation was significant. In all treatment groups, chromosomal aberrations like gaps, breaks and ploidy observed, were less significant. Results obtained were recorded and evaluated.


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