ARTICLE
Year : 2004  |  Volume : 11  |  Issue : 2  |  Page : 55-62

Study on the changes in glycolipid levels during alcoholism and paracetamol toxicity in rats


Department of Biochemistry, University of Kerala, Kariavattom P.O., Thiruvananthapuram, Kerala-695 581, India

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D S Jaya
Department of Biochemistry, University of Kerala, Kariavattom P.O., Thiruvananthapuram, Kerala-695 581
India
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The changes in the levels of various glycolipid fractions during alcoholism and paracetamol toxicity were studied in rats. Rats were given different doses (1.195 g/kg body wt., 3.55 g/kg body wt. and 7.11 g/ kg body wt.) of ethanol for three months. A single oral dose of paracetamol (400 mg/kg) was given to one set of alcoholic rats and to one set of normal rats. Liver injury was assessed biochemically by measuring the activities of glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) in serum that were found to be increased in the different doses of alcohol treated rats and in the paracetamol administered normal and alcoholic rats. The ethanol administration in different doses and the paracetamol treatment to rats resulted in the increase of neutral glycosphingolipids, glycoglycerolipids, sulfatoglyco-sphingolipids and ganglioside levels in the liver and brain. The increased concentration of neutral glycosphingolipids especially cerebrosides may cause abnormal changes in the spinal cord and white matter of the brain. Also the observed elevated levels of liver and brain gangliosides in the alcohol treated rats and in the paracetamol administered rats may cause alterations in the membrane structure of these tissues and various cell surface phenomena.


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