ARTICLE
Year : 2004  |  Volume : 11  |  Issue : 2  |  Page : 103-106

Effect of Photodynamic therapy on the chemically transformed tissue of mice


Department of Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum - 695 011 (Kerala), India

Correspondence Address:
A K Gupta
Department of Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum - 695 011 (Kerala)
India
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Photodynamic effect of He-Ne laser along with the photosensitiser 5- Aminolevulinic Acid was studied in the chemically transformed tissue of mice. Skin carcinoma was induced chemically in Swiss mice by painting the carcinogen 7,12-Dimethyl Benz (a) anthracene (DMBA) and the promoter croton seed oil. The experiment was scheduled with four groups consisting of ten animals each. Group I served as control, group II received only laser, group III received only photosensitiser and group IV received laser 24 hours after the injection of photosensitising agent 5- Aminolevulinic Acid (ALA). Each tumor field was irradiated with laser energy ranging from 75 to 100 J/cm2. The results of the study indicated that the potential use of laser with ALA significantly reduced the number of papillomas compared to the control group.


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